In a recent study, researchers led by Prof. LI Xinjian from the Institute of Biophysics have uncovered a novel immunoregulatory function of isocyanic acid (ICA), a reactive metabolite synthesized by the enzyme laccase domain containing 1 (LACC1).
A study led by Prof. NIE Guangjun and Prof. LI Suping from the National Center for Nanoscience and Technology of the Chinese Academy of Sciences revealed a close connection between platelets and antitumor immunity, offering a promising strategy to overcome the limited response of PD-1 therapy.
A recent study by Chinese scientists has revealed the intricate molecular machinery driving energy exchange within chloroplasts, shedding light on a key event in the evolution of plant life. Led by FAN Minrui from the Center for Excellence in Molecular Plant Sciences of the Chinese Academy of Sciences, the research elucidates the structure and function of the ATP/ADP translocator—a crucial member of the nucleotide transporter (NTT) family of proteins—which facilitates the transfer of energy across chloroplast membranes.
Researchers from the South China Botanical Garden of the Chinese Academy of Sciences discovered that unlike nursery plants, which adopt an acquisitive strategy in resource-abundant conditions, island plants exhibit stronger leaf structures and higher antioxidant capacities. These traits represent a tolerance strategy that enables them to better withstand environmental stresses.
A team led by Prof. LIU Hong and Prof. YANG Caiguang from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences identified compound 18l as a covalent inhibitor targeting non-catalytic Cys200 residue of ALKBH5, verified its Cys200 covalent mechanism, in vitro and in vivo activity, and most importantly, demonstrated intracellular targeting of ALKBH5.
A research team led by Prof. ZENG Zhutian from the University of Science and Technology of China identified a novel population of bladder-resident macrophages and named them suburothelial perivascular macrophages (suPVMs), which can prevent hematogenous dissemination of uropathogens by releasing macrophage extracellular traps (METs).
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