Prof. CHEN Yihua’s lab at the Institute of Microbiology of the Chinese Academy of Sciences (IMCAS), collaborating with Prof. SHAO Feng from National Institute of Biological Sciences, and Prof. WU Bian from IMCAS, expanded the distribution of heptose biosynthetic enzymes (HBEs) and the structural diversity of NDP-heptoses.
A recent study by researchers from Wuhan Botanical Garden (WBG) of the Chinese Academy of Sciences may have found the genetic code for the mechanism underlying the ripening and softening of kiwiberry. This study analyzed the postharvest ripening process of kiwiberry and revealed that pectin solubilization and hemicellulose depolymerization were the primary contributors to fruit softening.
A recent research led by Prof. ZHAO Yan from the Institute of Biophysics of the Chinese Academy of Sciences revealed for the first time the three conformations during the transport process of human dopamine transporter (DAT), identified the substrate binding sites and ion binding sites of human DAT, and intuitively explained the coupling relationship between ion binding and substrate transport.
A team of researchers led by Prof. LIU Xingguo from the Guangzhou Institutes of Biomedicine and Health and Prof. ZHANG Qingjiong from Zhongshan Ophthalmic Center, discovered that mesenchymal stem cell (MSC)-mediated mitochondrial transfer can effectively restore mtDNA and improve mitochondrial function in neural progenitor cells derived from patients with LHON.
A research team led by Prof. LI Xinjian from the Institute of Biophysics identified SLC13A3 as an intracellular transporter of itaconate and revealed that SLC13A3-mediated intracellular transport of itaconate can enhance the antimicrobial innate immunity of hepatocytes.
Recently, a collaborative research by Prof. LI Wei from the Institute of Biophysics of the Chinese Academy of Sciences and Prof. CHEN Ping from the Capital Medical University has unveiled for the first time the molecular mechanism by which the histone variant macroH2A regulates the nucleosome maintenance function of FACT through the critical S139 site.
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