The researchers firstly synthesized amphiphilic acid-sensitive block copolymer coupled with photosensitizer (pyrochloric acid, PPA) and phenylboric acid through hydrophobic interaction and π-π conjugation to encapsulate insoluble GPX4 inhibitor (RSL-3).
Then they found nanoparticles with external light can induce obvious ICD as well as cytotoxic T lymphocytes which secrete IFN-γ. IFN-γ and RSL-3 presented synergistically inhibition on the repairment axis and SystemXC--GPX4, while increased the accumulation of lipid-ROS in tumor cells, thus revealing the interaction between ferroptosis and immunotherapy.
Besides, the researchers found that the nanoparticles combined with immune checkpoint therapy (ICB) dramatically reduced the tumor-infiltration of dedifferentiated tumor cells in a manner of ferroptosis.
The study offered a new way to improve ferroptosis-mediated tumor immunotherapy.
A research team led by Prof. SHI Yufang found that, in addition to their direct inhibition on tumor growth, type I interferons (such as IFNα and IFNβ) also tuned MSCs to gain a tumor suppressive property. The tumor inhibition effect of IFNα is exerted through reversing...
A research team led by LI Yaping and ZHANG Pengcheng from Shanghai Institute of Materia Medica of the Chinese Academy of Sciences demonstrated that the paradoxical effects of IFN supplementary therapy could be addressed using a T lymphocyte membrane-decorated epigenetic n...
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