The researchers firstly synthesized amphiphilic acid-sensitive block copolymer coupled with photosensitizer (pyrochloric acid, PPA) and phenylboric acid through hydrophobic interaction and π-π conjugation to encapsulate insoluble GPX4 inhibitor (RSL-3).
Then they found nanoparticles with external light can induce obvious ICD as well as cytotoxic T lymphocytes which secrete IFN-γ. IFN-γ and RSL-3 presented synergistically inhibition on the repairment axis and SystemXC--GPX4, while increased the accumulation of lipid-ROS in tumor cells, thus revealing the interaction between ferroptosis and immunotherapy.
Besides, the researchers found that the nanoparticles combined with immune checkpoint therapy (ICB) dramatically reduced the tumor-infiltration of dedifferentiated tumor cells in a manner of ferroptosis.
The study offered a new way to improve ferroptosis-mediated tumor immunotherapy.
Chinese researchers have made a breakthrough in the treatment of cancer through immunotherapy, identifying a particular hormone receptor as a potential target for the treatment, the University of Science and Technology of China said. The receptor, MC5R, acts with a hormon...
A research team led by Prof. LIANG XingJie from the National Center for Nanoscience and Technology of the Chinese Academy of Sciences and Prof. LI Jinghong from Tsinghua University proposed a new strategy for constructing transformable nanocarriers to improve antigen deli...
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