The researchers proposed a strategy to study the whole in vivo metabolism and chemical transformation of nanomaterial by integrating multi-disciplinary techniques, such as in-situ characterization of protein corona, metabolic analysis methods, proteomics, and molecular dynamics simulations.
As an example, in vivo biological behaviour of two-dimensional transition metal dichalcogenide nanomaterial MoS2 bridged by protein corona was studied systematically.
With the proteomics and molecular dynamics simulations, the researcher revealed the interaction mechanism of MoS2 with blood proteins and the functions of protein corona.
A research team led by LI Yaping and ZHANG Pengcheng from Shanghai Institute of Materia Medica of the Chinese Academy of Sciences demonstrated that the paradoxical effects of IFN supplementary therapy could be addressed using a T lymphocyte membrane-decorated epigenetic n...
Researchers from the Institute of Process Engineering and their collaborators have developed a ferritin (Fn)-based nanomedicine for targeted delivery of arsenic (As) and efficient therapy against diverse leukemia types.
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