Since South China Botanical Garden(SCBG)succeed in propagation and reintroduction of the first-grade rare and endangered plant of Primulina tabacum via biotechnology,the scientific researchers of SCIB recently carried out systematic studies on another first grade rare and endangered species Metabriggsia ovalifolia of the same family(Gesneriaceae)which is endemic to Guangxi Province,South China The Prof. MA Guohua from Plant Biotechnology Research Group of SCBG successfully induced adventitious shoot formation via shoot organogenesis with different explants(leaves and petioles)of M.
The research group lead by Prof. The determined crystal structure of danthron-bound RXR-LBD suggested a new mechanism for danthron antagonism to tetrameric RXR. These findings were expected to supply new insights into the structural basis of RXRa antagonist for its further potential therapeutic application. The ability to improve insulin sensitivity in vivo has made danthron a promising lead compound for the development of anti-diabetic drugs and supplied useful information for understanding the pharmacological mechanisms of rhubarb. Danthron binding induced conformational changes of RXR-LBD.
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