An international symposium entitled From Cage to Clinic: the Role of NHP in Basic Biomedical Research was held from Oct. 28 to 30 in Kunming, capital of southwest China's Yunnan Province.
During the past century almost every major medical advance has been made possible through research in animals, particularly nonhuman primates (NHP). Due to their close genetic, anatomical, physiological and behavioral similarity to humans, NHP provide an indispensable bridge between basic laboratory research (translational research) and human clinical use, the so called "bench to bedside". The purpose of translational research is to eventually test, in humans, novel therapeutic strategies developed through pre-clinical experimentation in animal models. However, the breadth of such translational bench to bedside research is often limited by external constraints posed by ethical and practical considerations. Our society is now facing enormous medical challenges that include SARS, AIDS, cancer, drug addiction, neurological illnesses, and cardiovascular diseases for which NHP provide the best models and the best hope for improved treatment. Therefore, NHP models provide a powerful means for evaluating biomedical interventions for prevention or treatment of human diseases. In addition, the ability to control genetic and environmental factors in captive NHP populations allows us to quantify the influence of each on risk factors and outcomes of complex diseases.
Sponsored by the CAS Kunming Institute of Zoology, experts in the field of bio-medical research were invited to discuss how to gain a better understanding of human disease processes using NHP models through the study of immune responses, regulation of cell survival and death, and genetic association, and to apply disease knowledge to the development of better diagnosis, prevention and treatment strategies for human diseases. More than 50 scholars from the U.S. the U.K. Italy, and South Korea attended the conference, focusing their topics on such issues as oncology, virology and immunology, neurobiology; reproductive & developmental biology; genetics & evolution; ecology & conservation; and standardization, care & ethic of NHP.