Chinese researchers have recently proposed a simple and effective index for early identification of high-risk population of diabetic complication.
Jointly accomplished by researcher led by Prof. WANG Yikun from the Hefei Institutes of physical science (HFIPS) of the Chinese Academy of Sciences and Prof. ZHOU Jian from the Shanghai Jiao Tong University Affiliated Sixth People's Hospital, this research has been published on Nutrition, Metabolism and Cardiovascular Diseases.
WANG Yikun and his team had developed a pain-free, non-invasive and fast scan equipment for early warning of diabetes, which could check the Advanced Glycation End Products (AGE) level concentrating in a person's skin tissue.
In recent years, WANG and his team have been busy deploying their equipment in hospitals, healthcare centers and community services. Based on the data collected by the equipment, they and their collaborators in hospitals conducted a clinical application research of AGE index in diabetic complications, such as diabetic lower extremity atherosclerosis disease (LEAD), diabetic carotid atherosclerosis (CAS) and so on.
Besides the AGE data, they also introduced other parameters collected by questionnaires, like family history of diabetes, medical history, smoking status, body mass index, blood pressure and other biochemical index, to build a database of 1,500 diabetics.
Through a systematic analysis of the combined data, they revealed the role of AGE in diabetes risk screening. Results show that AGE is a better index than glycosylated hemoglobin in early prediction of vision-threatening diabetic retinopathy.
In addition, considering the impact of aging on diabetes complications, the team first came up with a new index, called AGEage, that combines AGE with AGE to make better predictions.
The team believes that these clinical studies may provide evidence for AGE as a more appropriate indicator to reflect adverse prognosis of hyperglycemia and for better early identification of patients at high risk for LEAD and CAS, thereby facilitating the use of non-invasive AGE scanning equipment.
The non-invasive AGE scanning equipement. (Image by WANG's team)
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