A Chinese research team has developed a multicellular scaffold based on inorganic bioceramics for treating tendon-to-bone injuries.
Restriction of motor activity due to loss of natural structure is a major cause of decreased life quality in patients suffering from tendon-to-bone injuries.
To solve this problem, the research team, led by the Shanghai Institute of Ceramics (SIC) of the Chinese Academy of Sciences, combined manganese silicate (MS) nanoparticles with tendon/bone-related cells to construct an immunomodulatory multicellular scaffold to achieve integrated tendon-to-bone regeneration.
The scaffold not only demonstrated diverse biological activities in vitro, but also achieved immune regulation, multi-tissue integration regeneration and motor function recovery in a variety of animal models of rotator cuff injury.
The study provides a new concept for achieving immunomodulation and integrated regeneration of tendon-bone and other tissue interfaces, said Wu Chengtie with the SIC, who led the research.
The study was recently published in the journal Science Advances. (Xinhua)
A research group led by Prof. WU Chengtie from the Shanghai Institute of Ceramics has developed a multicellular scaffold based on inorganic bioceramics to achieve immunomodulation and integrated regeneration in tendon-to-bone injuries, i.e., injuries occurring at the tendon–bone interface.
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