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Next Generation of Bio-based Polymeric Hollow Fiber Membrane for Hemodialysis

Jan 25, 2013

A special type of dialysis membrane module, called dialyzer (Fig.1), is used in the pressure-driven hemodialysis process to remove excess waste products and water from the body. Treatments take from four to six hours and usually are performed three times a week. The materials requirement for blood purification is very strict, and therefore, membrane materials which can be used in clinical application are actually very few. Cellulose and polysulfone are two main membrane materials, and the related technologies are now monopolized by a few companies like Fresenius, Gambro, and Baxter.

 
  Fig.1 PLA module for hemodialysis
Recently, the functional membrane group led by Professor XUE Lixin and Associate professor LIU Fu from the Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences (NIMTE), developed a new bio-based polymeric hollow fiber membrane for the use of hemodialysis, which has been proved with excellent dialysis performances, good bio-compatibility and well controlled degradation capacity. The new hollow fiber membrane is promising to be used in hemodialysis and replace the traditional petroleum based polymer membranes.

Polylactide (PLA) possesses better bio-compatibility, lower producing cost, and more importantly, it comes from renewable resources and is independent on petroleum based materials. Moreover, PLA is a polymer that can be buried and degraded after use, which is helpful to reduce the reverse impact on the environment.

 
 Fig.2 Cross section of PLA hollow fiber
The group has been conducting the fundamental research for years on polylactide hollow fiber membranes for the use of hemodialysis. The researchers have been focusing on exploring the thermal dynamics and kinetics of polylactide systems, controlling the micro-structure of membranes, tuning the phase inversion protocol, and grafting heparin through in-situ polymerization. They obtained a series of PLA hollow fiber membrane with the wall thickness 40~100μm, and inner diameter 200~450μm. The prepared PLA module has a flux of 42 ml/H•m2•mmHg, the urea clearance of 90%, and the middle molecular weight metabolites clearance of 35% (Fig.2).

Up to now, a related patent has been filed (201210547368.0).

Professor XUE Lixin: xuelx@nimte.ac.cn

Research Group Url: http://english.nimte.cas.cn/rh/rd/fpm 

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