
Prof. Chen Zhu, vice president of CAS and director of Shanghai Institute of Hematology, was elected as a foreign associate of the French Academy of Sciences on June 21.
The French Academy of Sciences comprises members, foreign associates and correspondents, who are selected from among the most eminent scholars. This year 17 foreign associates were elected into the French academy.
Born in Shanghai in 1953, Chen Zhu obtained his master's degree in medical science at Shanghai Second Medical University in 1981 and his doctoral degree at Institute of Hematology, Hospital Saint-Louis, University Paris VII, Paris, France, in 1989.
Prof. Chen conducted the first study in China to precisely classify hemophilia A and to perform carrier detection and genetic counseling of hemophilia A using advanced technology. He revealed the regulation of TCR gene rearrangement and expression in human malignant lymphocytes. In the study on leukemia related genes, he was the first to establish a molecular model of BCR-ABL rearrangement, and described different fusion genes to be the result of specific chromosomal translocation in acute promyelocytic leukemia (APL). He and his group made important discoveries in exploring the mechanisms of differentiation induction by ATRA and apoptois induction by As2Oe in the treatment of APL. Recently, as one of the coordinators of the Human Genome Project (HGP) in China, Prof. Chen has been participating in the planning and organization of this project. He and his colleagues have established a relatively comprehensive technology system for genomic DNA and cDNA mapping, cloning, sequencing and bioinformatics analysis, and identified a large number of genes regulated by ATRA. In addition, his group was the first to describe a gene expression profile of the hematopoietic stem/progenitor cells (HSPCs), and cloned dozens of full length cDNA of novel genes in HSPCs.
Prof. Chen's pioneering work is recognized worldwide, and received many rewards and honors. For instance, he was elected a fellow of the Academy of Science for Developing World (TWAS) in 1989, a member of CAS in 1995, and a foreign associate of the US National Academy of Sciences in 2003. He was awarded Chevalier de l'Ordre National de la Lëgion d'Honneur, France in 2002, and conferred Doctor of Science
honoris causa by University of Hong Kong and University Paris VII, Paris, in March and May 2005, respectively.