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Chinese Researchers Develop Smart Tumor-targeting Nanoparticles

Jun 29, 2020

Chinese researchers have developed biodegradable tumor-targeting nanoparticles, which provides a promising therapy for tumor treatment, according to the Chinese Academy of Sciences (CAS).

A joint research team with scientists from the CAS developed the tumor-targeting nanoparticles as a combination of tumor-infarction therapy and chemotherapy, said the CAS.

It has long been a challenge for researchers to find a safe and effective therapy for vascular thrombosis. Drugs that induce thrombosis in the tumor vasculature have not resulted in long-term tumor eradication.

The CAS research team developed the nanoparticle, a type of DNA nanorobot that can precisely send the thrombin to the tumor-vessel walls and the tumor stroma, leaving the tumor to "starve to death."

Study results showed that the co-administration of a cytotoxic payload and a protease to elicit vascular infarction in tumors with biodegradable tumor-targeting nanoparticles represented a promising strategy for improving the therapeutic index of coagulation-based tumor therapy.

The study has been published online by the journal Nature Biomedical Engineering. (Xinhua)

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Combination of tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles

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