Chinese scientists have discovered that a small-molecule probe can detect lung disease pulmonary fibrosis (PF) in mice, said a recent research paper published in the journal Analytical Chemistry.
Pulmonary fibrosis is a fatal disease with increasing prevalence. The scientists from the Shanghai Institute of Materia Medica under the Chinese Academy of Sciences worked with Zhejiang University to develop the small-molecule probe PNO1 which can sense the micro-environmental features of the PF, typically, the nitric oxide level in PF-diseased lungs.
The scientists found that the PF-diseased mice injected with the PNO1 probe showed lung fluorescence intensity six times higher than the normal mice. PNO1 fluorescence in mice lungs also changed in response to a PF therapy which has been approved in China, said the paper.
This detection method is expected to be efficiently used in anti-PF medicine evaluation in the future. (Xinhua)
A Chinese research team from Institute of Intelligent Machines has developed an effective colorimetric fluorescent detection of lead ions in water, and achieved visual, real-time and semi-quantitative detection by printing the paper strip with fluorescence probe solution...
A research group led by Prof. XU Zhaochao from the Dalian Institute of Chemical Physics, as well as LIU Xiaogang’s group from Singapore University of Technology and Design, recently reported a reliable prediction method for twisted intramolecular charge transfer (TICT) f...
86-10-68597521 (day)
86-10-68597289 (night)
86-10-68511095 (day)
86-10-68512458 (night)
cas_en@cas.cn
52 Sanlihe Rd., Xicheng District,
Beijing, China (100864)
Copyright © 2002 - Chinese Academy of Sciences
