Scientists Discover Alterations in Salivary Redox Status and Fatty Acid Metabolism Association with Inflammation and Oxidative Stress in Periodontal Disease
May 03, 2014 Email"> PrintText Size
Periodontal diseases represent the most common chronic inflammatory diseases in humans and a major cause of tooth loss. Periodontitis is a complex multifactorial disease and accumulating evidence indicates that chronic inflammation, redox imbalance, and oxidative stress contribute to the disease onset and progression. However, the exact mechanism that leads to local and systemic redox alteration in periodontal diseases remains poorly defined.
A research team led by Dr. YIN Huiyong at the Institute for Nutritional Sciences (INS), Shanghai Institutes for Biological Sciences, identified significant alterations in redox status and fatty acids metabolism in saliva association with chronic inflammation and oxidative stress in periodontal disease in a cohort of nonsmoker subjects with chronic periodontitis using mass spectrometry-based ionomics and a targeted lipidomics on fatty acids metabolites. The researchers observed that levels of redox active metal ions including Mn, Cu, Zn in periodontal group were decreased, consistent with a decreased levels of superoxide dismutases (SODs) in saliva and serum. They also found that the major metabolites of arachidonic acid and linoleic acid in saliva, including PGE2, PGD2, and PGF2, TXB2, 5-HETE, were increased in periodontal group, and levels of salivary F2-isoprostanes, free radical lipid peroxidation products and a gold standard for oxidative stress in vivo, were also increased.
These observations highlight the importance of redox status in periodontitis and provide rationale to prevent periodontal disease by dietary interventions aiming to restore redox balance.
The article, entitled “Mass spectrometry-based metabolomic profiling identifies alterations in salivary redox status and fatty acid metabolism in response to inflammation and oxidative stress in periodontal disease”, was published in Free Radical Biology and Medicine.
The work was collaborated with Dr. ZHANG Meifang in the Department of Clinical Nutrition at the Shanghai No.9 People’s Hospital and was funded by grants of A29 from Shanghai Municipal Mission of Health and Family Planning (20114103), Ministry of Science and Technology of China (2012BAK01B00), National Key Basic Research Program of China (973 Program, #2012CB524900), National Natural Science Foundation of China (31170809), and Hundred Talents Program from CAS (2012OHTP07).
Contact:
YIN Huiyong, Principle Investigator
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,
Shanghai 200031, China.
Tel: 86-21-54920942
Fax: 86-21-54920291
Email: hyyin@sibs.ac.cn
Periodontal diseases represent the most common chronic inflammatory diseases in humans and a major cause of tooth loss. Periodontitis is a complex multifactorial disease and accumulating evidence indicates that chronic inflammation, redox imbalance, and oxidative stress contribute to the disease onset and progression. However, the exact mechanism that leads to local and systemic redox alteration in periodontal diseases remains poorly defined.
A research team led by Dr. YIN Huiyong at the Institute for Nutritional Sciences (INS), Shanghai Institutes for Biological Sciences, identified significant alterations in redox status and fatty acids metabolism in saliva association with chronic inflammation and oxidative stress in periodontal disease in a cohort of nonsmoker subjects with chronic periodontitis using mass spectrometry-based ionomics and a targeted lipidomics on fatty acids metabolites. The researchers observed that levels of redox active metal ions including Mn, Cu, Zn in periodontal group were decreased, consistent with a decreased levels of superoxide dismutases (SODs) in saliva and serum. They also found that the major metabolites of arachidonic acid and linoleic acid in saliva, including PGE2, PGD2, and PGF2, TXB2, 5-HETE, were increased in periodontal group, and levels of salivary F2-isoprostanes, free radical lipid peroxidation products and a gold standard for oxidative stress in vivo, were also increased.
These observations highlight the importance of redox status in periodontitis and provide rationale to prevent periodontal disease by dietary interventions aiming to restore redox balance.
The article, entitled “Mass spectrometry-based metabolomic profiling identifies alterations in salivary redox status and fatty acid metabolism in response to inflammation and oxidative stress in periodontal disease”, was published in Free Radical Biology and Medicine.
The work was collaborated with Dr. ZHANG Meifang in the Department of Clinical Nutrition at the Shanghai No.9 People’s Hospital and was funded by grants of A29 from Shanghai Municipal Mission of Health and Family Planning (20114103), Ministry of Science and Technology of China (2012BAK01B00), National Key Basic Research Program of China (973 Program, #2012CB524900), National Natural Science Foundation of China (31170809), and Hundred Talents Program from CAS (2012OHTP07).
Contact:
YIN Huiyong, Principle Investigator
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,
Shanghai 200031, China.
Tel: 86-21-54920942
Fax: 86-21-54920291
Email: hyyin@sibs.ac.cn
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