
Recently
Nature China reported a finding made by WANG Mingwei and his team. In collaboration with Sichuan University West China School of Pharmacy, WANG Mingwei and co-workers from the CAS Shanghai Institute of Materia Medica have discovered a class of androgen-receptor modulators that may result in a better treatment of prostate cancer.
After a high-throughput screening of 16,000 synthetic or natural compounds for their binding to androgen receptors, researchers focused their efforts on a series of non-steroidal compounds derived from 3-(phenylamino) -propan- 1- one. These chemicals interact with androgen receptors with a high affinity, thereby preventing dihydrotestosterone from binding. Binding of androgens to their receptors leads to the activation of target genes and cell proliferation. Researchers tested whether their compounds could affect such cellular processes. They found that some of the derivatives work as 'agonists', having similar biological effects as androgens, whereas other derivatives are 'antagonists', interfering with the hormones' actions.
Started in 2003, the project has been financed by Chinese Ministry of Science and Technology, CAS, National Natural Science Foundation, and Shanghai Municipal S&T Committee. So far a number of findings derived from the project have applied for both domestic and international patents for invention.
Prof. REN Nanqi observed in 1990 a phenomenon indicating that hydrogen producing bacteria would produce hydrogen in the course of organic waste water treatment. From that time on, REN and coworkers have worked many years to develop a technology that is able to produce hydrogen from organic waste water, while decomposing organic matters and purifying waste water. Researchers completed a limited scale experiment to extract hydrogen from organic waste water using a fermentation process in the period from 1990 to 1996. They furthered their pilot study during the period of 1996-1999, and developed a proprietary biotechnique to produce hydrogen from organic waste water. The project was financed by a National 973 Program in 2000-2005, during which a new class of strains was discovered by researchers. The new strain makes a fine catalyst in producing hydrogen, with an easy demand for environment, which makes massive production of hydrogen possible. REN and coworkers established in 2005 a fermentation based hydrogen producing line with a daily capacity of 1200 cubic meters, the first of its kind in the world, under a demonstration project financed by the National 863 Program.