Hepatocellular carcinoma cell growth in vitro was suppressed by 6-fluoro-3-formylchromone through cell cycle arrest that induced apoptosis, according to data from a recent study.
Researchers bought human
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Researchers also tested FCC’s effect on PCNA, Bax and Bcl-2 protein expressions and learned that PCNA and Bcl-2 were suppressed (P<.05), while Bax increased, according to Western blot analysis. FCC induced apoptosis in HCC cells by increasing the Bax/Bcl-2 ratio.
"Our data demonstrated that FCC could inhibit the proliferation of SMMC-7721 cells in vitro and it could down-regulate PCNA and Bcl-2 expression and up-regulate Bax expression,” researchers said. “The results indicated that FCC could be developed as a novel anti-tumor agent for treating HCC.” (Halio.com)
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