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SOX2; hESCs; hNPCs; Wnt; H2A.Z

Scientists Discover Mechanisms Underlying SOX2-mediated Cell Fate Specification in human ESCs and NPCs[Mar 01, 2016]

A joint effort by Dr. JIN Ying’s lab at Institute of Health sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Dr. ZHANG Yong’s lab at Tongji University performed a comprehensive comparative study of the transcription networks and protein interactome of SOX2 in hESCs and hNPCs using ChIP-seq, RNA-seq and protein mass spectrometry.

Root Organogenesis;Organ Emergence;Genetic Pathway

Study Reveals New Genetic Pathway for Organ Emergence during de novo Root Organogenesis[Mar 01, 2016]

De novo root organogenesis refers to the regeneration of adventitious roots from detached or wounded plants organs/tissues. Using an adventitious rooting system from detached leaf explants, the framework of cell fate transition has been recently uncovered. Briefly, the WOX11 transcription factor gene is induced by the plant hormone auxin upon detachment of leaf explants, leading to the fate transition from regeneration-competent cells to root founder cells. Subsequently, root founder cells undergo rounds of cell division to form the root primordium.

Arabidopsis; WRKY57; transgenic rice;  drought stress; overexpression

Arabidopsis WRKY57 Transcription Factor Confers Drought Tolerance to Transgenic Rice Plants[Mar 01, 2016]

The previous study gave them a hypothesis that the improvement of plant drought tolerance might be realized through gene manipulation approaches. To explore whether AtWRKY57 played an important role in improving the agronomic traits through gene manipulation approaches, the researchers introduced this gene to rice and evaluated the role of AtWRKY57 in transgenic rice after drought stress.

Plant thermotolerance; Thermotolerant Growth Required1; RNA helicase

IGDB Scientists Reveal Key Mechanism of Plant Thermotolerance[Feb 26, 2016]

Collaborated research from XUE Yongbiao’s lab and CHENG Zhukuan’s lab, both from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, identified a novel gene, Thermotolerant Growth Required1 (TOGR1) from a thermosensitive rice mutant (togr1-1) which encodes a DEAD-box RNA helicase and confers thermotolerant growth as an intrinsic rRNA chaperone by maintaining rRNA homeostasis under heat stress.


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