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Calreticulin; LC3; LC3-interacting region (LIR motif); autophagy; Chaperone

Key Endoplasmic Reticulum Chaperone's Novel Role Revealed in Negative Feedback Regulation of Cellular Stress[Nov 16, 2018]

Based on the previous findings that berberine relieves hepatic steatosis and maintains energy balance by activating autophagy and FGF21 signaling, a team of researchers led by Prof. LI Yu at Shanghai Institute of Nutrition and Health of Chinese Academy of Sciences discoverd that a quality-control ER chaperon, Calreticulin, is induced under ER stress and triggers autophagy via interacting with MAP1LC3 (LC3).

immune;agonist antibody;utomilumab;4-1BB

How to Refuel the T-cells——the Guardians for Anti-tumor Immunotherapy?[Nov 16, 2018]

Modulation of T- cell mediated anti-tumor immune responses with monoclonal antibodies (mAbs) has achieved the brilliantly clinical success. Agonist mAbs targeting co-stimulatory 4-1BB, including urlumab (Bristol-Myers Squibb) and utomilumab (pfizer), have shown the promising efficacy in treatment of multiple tumors when combined with other immunotherapies. How do the antibodies work? Scientists from Suzhou Institute of Biomedical Engineering and Technology (SIBET) and The Institute of Microbiology of the Chinese Academy of Sciences (IMCAS) dissected the molecular mechanism of antibodies.

database;data center;curation;big data;omics data

A Series of Featured Databases Released by the BIG Data Center[Nov 16, 2018]

Based on big data integration and value-added curation, recently, the BIG Data Center at the Beijing Institute of Genomics of Chinese Academy of Sciences, constructed a series of featured databases, including EWAS Atlas (a knowledgebase of epigenome-wide association studies), iDog (an omics data resource for dog), EDK (Editome Disease Knowledgebase), PED (Plant Editosome Database), LncBook (a knowledgebase of human long non-coding RNAs), and NucMap (Nucleosome Positioning Map).

Kagome lattice;silicene;flat band;scanning tunnelling microscopy;silicene;nanosheet

Scientists Create Atomic Scale, Two Dimensional Electronic Kagome Lattice in Silicene[Nov 16, 2018]

Scientists from the Institute of Physics (IOP), working with colleagues at University of Wollongong in Australia, Beihang University, and Nankai University (NKU), have successfully created an atomic scale, two-dimensional electronic Kagome lattice in multilayer silicene, which has potential applications in electronics and quantum computing.

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