/   Home   /   Newsroom   /   Research in China

American, Chinese Scientists Find New Way to Prevent, Treat Alzheimer's Disease

Mar 08, 2018     Email"> PrintText Size

American and Chinese scientists reported on Wednesday in the journal Neuron how a receptor on the immune cell in the brain helps prevent or reduce severity of Alzheimer's disease, a neurodegenerative disorders affecting 47 million people worldwide.

The study, led by Xu Huaxi, a neuroscientist from Sanford Burnham Prebys Medical Discovery Institute, has shown that a receptor called TREM2 can interacts with toxic amyloid beta proteins to restore neurological function.

Xu said, TREM2 can bind specifically to oligomers of amyloid beta, the main component of the plaques found in the brains of Alzheimer's patients.

An increasing TREM2 level renders the immune cell called microglia more responsive and reduces Alzheimer's disease symptoms. Microglia is a brain cell known to be able to eat up amyloid beta.

Without TREM2, however, microglia were much less successful at binding to, and clearing out, amyloid beta. Also, removing TREM2 downregulates microglial potassium ion channels, thus impairing the electrical currents associated with the activation of these immune cells.

"This new research reveals specific details about how TREM2 works, and supports future therapeutic strategies to strengthen the link between amyloid beta and TREM2," said Xu.

Researchers found that the added TREM2 signaling stopped disease progression and even restored cognitive function.

"Going after microglia, rather than amyloid beta generation, may be a new research avenue for Alzheimer's disease," said Xu.

Researchers from Fujian Medical University, Xiamen University, University of Texas and University of California Los Angles participated in the study. (Xinhua)


(Editor: LIU Jia)



Related Articles

Alzheimer's disease;flavonoids;cotton petal

Chinese Researchers Find Flavonoids in Cotton Petals to Treat Alzheimer's

Jan 04, 2016

A new drug to treat Alzheimer's disease that uses flavonoids found and extracted by Chinese researchers from cotton petals has entered clinical trial. Researchers at Xinjiang Technical Institute of Physics and Chemistry under the Chinese Academy of Sci...

Alzheimer; Alzheimer's disease; AD; AD16; GIBH

China's New Alzheimer's Disease Drug Applies for Clinical Tests

May 25, 2015

China will begin clinical tests on a new drug for Alzheimer's disease (AD), after animal tests showed positive results. AD16, developed by Guangzhou Institute of Biomedicine and Health (GIBH) under the Chinese Academy of Sciences, has proven effective ...

expression profile;regulatory network;Alzheimer's disease

YAP1 and Other Prioritized Hub Genes Identified As Important Upstream Regulators in Alzheimer's Disease

Nov 28, 2017

Recently, the research group led by Prof. YAO Yonggang at Kunming Institute of Zoology of Chinese Academy of Sciences identified several upstream regulator genes which may play a crucial role in regulatory network of gene expression in Alzheimer’s dis...

Contact Us

Copyright © 2002 - Chinese Academy of Sciences