/   Home   /   Newsroom   /   Research in China

HK Researchers Find Effective Drug to Suppress Superbugs

Feb 09, 2018     Email"> PrintText Size

A kind of drug used for treating peptic ulcer was found effective in suppressing the activity of drug-resistant superbugs in a research done by the University of Hong Kong which made the results public on Thursday.

Antimicrobial resistance posed by superbugs has been a major public health issue of global concern. Drug-resistant infections kill around 700,000 people worldwide each year, and the figure could increase up to 10 million by 2050, according to figures of the World Health Organization.

The university's research team discovered that colloidal bismuth subcitrate (CBS), an antimicrobial drug against Helicobacter pylori-related ulcer, can effectively paralyze multidrug-resistant superbugs, including Carbapenem-resistant Enterobacteriaceae (CRE) and Carbapenem-resistant Klebsiella pneumoniae (CRKP), which can cause deadly infections such as bacteremia, pneumonia, and wound infections.

NDM-1 (New Delhi Metallo-Beta-lactamase 1) is one of the leading resistant determinants that demonize common bacteria into CRE superbugs. The NDM-1 carrying CREs is lethal and extremely difficult to treat, which poses a great threat to public health. Scientists report that NDM-1 superbugs have now been disseminated to over 70 countries or regions across the world.

The research team revealed that CBS can "tame" the superbug by reducing it to almost sensitive strain which can be easily killed by commonly used Carbapenem antibiotics.

More importantly, the brand-new therapy allows the dose of antibiotics to be reduced by 90 percent to attain the same level of effectiveness, and the development of NDM-1 resistance to be significantly slowed down, which will largely extend the life cycle of currently used antibiotics.

"We hope CBS-based combination therapy will open up a new horizon for the treatment of infection caused by superbugs, serving as a new and more economical therapy to solve the problem of antimicrobial resistance," said Sun Hongzhe, professor of the university's chemistry department.

The findings were published in Nature Communications in January 2018 and a patent has been filed in the United States for the discovery. (Xinhua)

Attachment:

(Editor: LIU Jia)

Contact

Phone:
E-mail:

Related Articles

antimicrobial resistance;bacterial pathogen infection;sewage;antimicrobial resistance;wastewater

Scientists Map the Distribution of Antimicrobial Resistance across Chinese Major Cities

Jul 28, 2017

Professor ZHU Yongguan from Institute of Urban Environment and his collaborators recently conducted a nation-wide survey of antimicrobial resistance elements in urban sewage and depicted that the distribution of antimicrobial resistant genes was charac...

superbug;drug resistance;antibiotic

New Superbug Could Be Epidemic, Scientists Find

Mar 22, 2017

Chinese scientists have discovered a new drug-resistant strain of bacteria that can spread stealthily and has epidemic potential. The superbug is a strain of Salmonella typhimurium whose plasmid - mobile DNA that can be easily copied and shared between...

superbug;antibiotic;MCR-1;bacteria;gene

Superbug Gene Against All Forms of Antibiotics Discovered in China

Nov 23, 2015

Researchers at South China Agricultural University, lead by Liu Jianhua, have discovered a gene in China, called MCR-1, which makes bacteria resistant against polymyxins. These are antibiotics seen as a last-line of defence for humans in the fight agai...

Contact Us

Copyright © 2002 - Chinese Academy of Sciences